Nobilis® IB 4/91

Description
Nobilis IB 4/91 is a live vaccine for the immunization of chickens against Infectious Bronchitis serotype 4-91 and related serotypes.

Composition
Active components per dose:
Live IBV strain 4/91: >= log¹⁰ 3.6 EID₅₀

Formulation
A freeze-dried pellet.

Indications
Vaccination of chickens against Infectious Bronchitis serotype 4-91 or related serotypes.

Vaccination
Single dose vaccination against IB serotype 4/91 and related serotypes can be carried out at two weeks of age. If problems due to this disease occur before 14 days of age, vaccination during the first week (1-7 days) of life, and re-vaccination at three weeks of age is recommended. The broadest protection is obtained when a vaccination with Nobilis IB Ma5 (day 0) is followed by a vaccination with Nobilis IB 4/91 (14 days of age).

Dosage
One dose per bird.

Method of administration
The optimum time and method of administration depend largely upon the local situation and veterinary advice should be sought on an individual basis. The vaccine may be administered by coarse spray, drinking water or by the intranasal/ocular route.

– Spray method
The vaccine should be dissolved in cool, clean water which is free of iron and chlorine. The vials should be opened under water. The spray apparatus should be free from sediments, corrosion and traces of disinfectants (preferably used for vaccination purpose only). The vaccine medicated water should be sprayed evenly over the correct number of birds, at a distance of 30 to 40 cm, preferably when the birds are sitting together in dim light. For day old chicks use 0.25 liter for 1000 birds and for older birds use 0.5 liter for 1000 birds and set the nozzle to produce a coarse spray.

– Intranasal / intraocular instillation
Dissolve the vaccine in physiological saline solution (usually 30 ml per 1000 doses) and administer by means of a standardised dropper. One drop should be applied from a height of a few centimetres into one nostril or one eye. The handler should ensure that the nasal drop is inhaled by the bird.Note: For intranasal / intraocular administration a special diluent, Diluent Oculo Nasal is available.

– Drinking water
The vials should be opened under water. Use cool, clean water which is free of iron and chlorine. By adding 2 gm skimmed milk powder per litre of water the virus retains its activity much longer.
Ensure uptake of all the vaccine-medicated water in 2 hours. Depending on the weather conditions, it may be advisable to deprive the birds of water prior to vaccination . A sufficient number of water containers to provide adequate drinking space is essential. These should be clean and free from traces of detergents and disinfectants. Dissolve 1000 doses in as many litres of water as the age of the birds in days, to a maximum of 40 litres. The vaccine should be given in the early morning as this is the main period for drinking or the cool period on a hot day. When vaccinating larger flocks, it is advisable to begin by dissolving only part of the vaccine. If vaccine is administered through a central water supply or a proportioner, great care should be taken. For numbers of birds between standard dosages, the next higher dosage should be chosen.

Note: Administration by coarse spray or the oculo-nasal route gives the best response. These should be the methods of choice, especially when vaccinating young birds.

Withholding period
None

Presentation
A 10 ml glass vial of hydrolytical class type II containing 1000 or 2500 doses of freeze dried dried vaccine. The vial is closed with a halogenobutyl rubber bung and sealed with a coded aluminium cap.

Storage
Store at a temperature of 2-8°C in the dark.

Contra-indications
When used according to instructions: None.

Further information
Dispose of empty or part-used vials in accordance with local regulations.

Precautions
– Wash and disinfect hands and equipment after vaccinating.
– Since the stability of IBV in suspension may be low, water used for dissolving the freezedried vaccine should be cool and of good quality. Skimmed milk powder should be added to the drinking water to improve the stability of the vaccine.